Muhammad Ali Loses to Larry Holmes October 2, 1980 – Sad Day
- Larry Holmes 211½ lbs
- Muhammad Ali 217½ lbs
- RTD at 3:00 in round 10 of 15
- Caesars Palace, Las Vegas, Nevada
- Referee: Richard Greene
- Judge: Chuck Minker 100-90
- Judge: Duane Ford 100-89
- Judge: Richard Steele 100-90
This was Muhammad Ali’s first fight since defeating Leon Spinks to regain the WBA heavyweight title on September 15, 1978. Ali announced his retirement in June 1979.
On July 17, 1980, Ali and Holmes signed to fight on October 2 at Caesars Palace in Las Vegas.
Caesars Palace constructed a temporary 24,790-seat outdoor arena for the fight. The live gate was $6 million, a record for that time.
Dr. Charles Williams, who was a member of Ali’s medical team, diagnosed Ali as having a thyroid imbalance and prescribed one tablet of Thyrolar per day. To make matters worse, Ali doubled the dosage because he “thought the pills would be like vitamins.”
Ali blamed the loss to Holmes on his use of Thyrolar and insisted, “I shall return.”